Collaborative research projects

Our group performs comprehensive proteomic approaches in a number of collaborative projects, covering a broad spectrum of biological aspects:

Platelets play a key role in haemostasis and various diseases including arterial thrombosis. Glycoprotein (GP) VI mediates adhesion to collagen structures exposed at sites of vascular injury and subsequent platelet activation. Together with Christian Schulz, Technical University of Munich (TUM), we determined the effects of specific activation of GPVI on the human platelet proteome.

In collaboration with the group of Daniel Wilson from the Gene Center, we investigate the proteome of archaeal ribosomes and their posttranslational modifications (e.g., lysine methylations), which led to the detection of so far unknown ribosomal proteins.

In a collaborative project with E. Wagner, Department of Pharmacy, LMU, we investigate the in vivo chemoresistance of prostate cancer cell lines.

Quantitative alterations in the glomerular proteomes of two transgenic mouse models for progressive kidney diseases are analysed in cooperation with R. Wanke, Institute of Veterinary pathology, LMU: Transgenic mice expressing a dominant negative glucose-dependent insulinotropic polypeptide receptor (GIPRdn) as a model of diabetes mellitus associated nephropathy, and growth hormone (GH)-transgenic mice, an established model of progressive glomerulosclerosis.

Together with Christian Laforsch, Department of Biology, LMU, we analyse the molecular basis of phenotypic plasticity in the model organism Daphnia. The Daphnia genome was recently published and found to contain the so far highest number of genes, many of them with no functional homologues in other species. These genes are supposed to be responsible for the excellent ability of Daphnia to adapt to environmental stress conditions.